Preclinical

Applications Notes

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2009

• ART Optix System for 3D in vivo Imaging of Gene Delivery Using Red Fluorescent Protein (PDF: 337 Kb)
• In vivo ADME/Tox Profiling Using the ART Optix System with a Novel Targeted Tumor NIR Fluorescent Optical Probe (PDF: 696 Kb)

2008

• Time-Resolved Fluorescence Imaging of Blood-Brain Barrier Disruption in Living Mice (PDF: 496 Kb)
• Fluorescence Lifetime Imaging of Renal Ischemia Reperfusion Injury (PDF: 516 Kb)
• Assessing murine lung tumor burden with fluorescent mAb therapy using the ART Optix, an in vivo fluorescent time-domain imaging system (PDF: 931 Kb)
• ART's Optix Small Animal Imager Applied to Non-Invasive Apoptosis Research in Mouse Xenograft Model (PDF: 707 Kb)
• The ART Optix small animal imaging system applied to cardiovascular research (PDF: 215 Kb)
• ART Optix quantitative analysis of multiple tumor targeting agents using fluorescence lifetime (PDF: 459 Kb)

Articles

• Early detection of human breast cancer MCF-7 using anti-EpCAM antibody conjugated with Cy5.5 (poster)
  Dao Chao Huang, Marilyse Piché, Muriel Jean-Jacques, Guobin Ma, and Mario Khayat
  2009 World Molecular Imaging Congress / September 23-26, 2009
  
• Quantitative in vivo 3D fluorescence lifetime imaging of a liver-specific agent (poster)
  Guobin Ma, Dao Chao Huang, Marilyse Piché, Muriel Jean-Jacques, Simon Fortier, Salim Djeziri, and Mario Khayat
  2009 World Molecular Imaging Congress / September 23-26, 2009
  
• Whole-body fluorescence lifetime imaging of human melanoma metastases in mice using Green Fluorescence Protein (GFP) (poster)
  Dao Chao Huang, Marilyse Piché, Muriel Jean-Jacques, Guobin Ma and Mario Khayat
  2009 World Molecular Imaging Congress / September 23-26, 2009
  
• Dynamic noninvasive monitoring of renal function in vivo by fluorescence lifetime imaging
  Reece J. Goiffon, Walter J. Akers, Mikhail Y. Berezin, Hyeran Lee, and Samuel Achilefu
  Journal of Biomedical Optics, Volume 14, Number 2 / March-April 2009
• Noninvasive Imaging of Liver Repopulation Following Hepatocyte Transplantation
  Sarah Koenig, Petra Krause, Ali Seif Amir Hosseini, Christian Dullin, Margret Rave-Fraenk, Sarah Kimmina, Andrew Lee Entwistle, Robert Michael Hermann, Clemens Friedrich Hess, Heinz Becker, and Hans Christiansen
  Cell Transplantation, Volume 18, Number 1 / 2009: pp. 69-78
• Long-term Cultures of Bone Marrow-Derived Human Mesenchymal Stem Cells Frequently Undergo Spontaneous Malignant Transformation
  Gro Vatne Røsland, Agnete Svendsen, Anja Torsvik, Ewa Sobala, Emmet McCormack, Heike Immervoll, Josef Mysliwietz, Joerg-Christian Tonn, Roland Goldbrunner, Per Eystein Lønning, Rolf Bjerkvig, and Christian Schichor
  Cancer Research, Volume 69, Number 13 / July 2009
• Concept of a selective tumour therapy and its evaluation by near-infrared fluorescence imaging and flat-panel volume computed tomography in mice
  Frauke Alves, Christian Dullin, Joanna Napp, Jeannine Missbach-Guentner, Katharina Jannasch, Julia Mathejczyk, Luis A. Pardo, Walter Stühmer, and Lutz-F. Tietze
  European Journal of Radiology, Volume 70, Number 2 / May 2009: pp. 286-293
• In vivo biodistribution and lifetime analysis of Cy5.5-conjugated rituximab in mice bearing lymphoid tumor xenograft using time-domain near-infrared optical imaging
  Stefania Biffi, Chiara Garrovo, Paolo Macor, Claudio Tripodo, Sonia Zorzet, Erika Secco, Francesco Tedesco, and Vito Lorusso
  Molecular Imaging, Volume 7, Number 6 / November-December 2008: pp. 272-282
• Transvascular accumulation of Sialyl Lewis X conjugated liposome in inflamed joints of collagen antibody-induced arthritic (CAIA) mice
  Jun Minaguchi, Toshitaka Oohashi, Kiichi Inagawa, Aiji Ohtsuka, and Yoshifumi Ninomiya
  Archives of Histology and Cytology, Volume 71, Number 3 / November 2008: pp. 195-203
• Nanohybrids via a polycation-based nanoemulsion method for dual-mode detection of human mesenchymal stem cells
  Sung-Baek Seo, Jaemoon Yang, Eun-Sook Lee, Yukyung Jung, Kyujung Kim, Sang-Yup Lee, Donghyun Kim, Jin-Suck Suh, Yong-Min Huh, and Seungjoo Haam
  Journal of Materials Chemistry, Volume 18, Number 37 / October 2008: pp. 4402-4407
• Dynamic analysis of the blood-brain barrier disruption in experimental stroke using time-domain in vivo fluorescence imaging
  Abedelnasser Abulrob, Eric Brunette, Jacqueline Slinn, Ewa Baumann, and Danica Stanimirovic
  Molecular Imaging, Volume 7, Number 6 / November-December 2008: pp. 248-262
• In vivo imaging and quantification of two tumor-targeting agents simultaneously using fluorescence lifetime (poster)
  Guobin Ma, Lysanne Melanson-Drapeau, Simon Fortier, Umar Iqbal, Niculae Mincu, Danica Stanimirovic, Mario Khayat, and Abedelnasser Abulrob
  2008 World Molecular Imaging Congress / September 10-13, 2008
• mTORC1 promotes survival through translational control of Mcl-1
  John R. Mills, Yoshitaka Hippo, Francis Robert, Samuel M. H. Chen, Abba Malina, Chen-Ju Lin, Ulrike Trojahn, Hans-Guido Wendel, Al Charest, Roderick T. Bronson, Scott C. Kogan, Robert Nadon, David E. Housman, Scott W. Lowe, and Jerry Pelletier
  Proceedings of the National Academy of Sciences (USA), Volume 105, Number 31 / August 2008: pp.10853–10858
• Leptin enhances the recruitment of endothelial progenitor cells into neointimal lesions after vascular injury by promoting integrin-mediated adhesion
  Marco R. Schroeter, Maren Leifheit, Philipp Sudholt, Nana-Maria Heida, Claudia Dellas, Ilonka Rohm, Frauke Alves, Marta Zientkowska, Stavros Rafail, Miriam Puls, Gerd Hasenfuss, Stavros Konstantinides, and Katrin Schäfer
  Circulation Research, Volume 103 / 2008: pp. 536-544
• Fluorescent magnetic nanohybrids as multimodal imaging agents for human epithelial cancer detection
  Jaemonn Yang, Eun-Kyung Lim, Hong Jae Lee, Joseph Park, Sang Cheon Lee, Kwangyeol Lee, Ho-Geun Yoon, Jin-Suck Suh, Yong-Min Huh, and Seungjoo Haam
  Biomaterials, Volume 29, Number 16 / June 2008: pp. 2548-2555
• Discovery of a phosphatidylserine-recognizing peptide and its utility in molecular imaging of tumor apoptosis
  Narendra Thapa, Soyoun Kim, In-Sup So, Byung-Heon Lee, Ick-Chan Kwon, Kuiwon Choi, and In-San Kim
  Journal of Cellular and Molecular Medicine, Volume 12, Number 5A / September-October 2008: pp.1649-1660
• Prolonging the in vivo residence time of prostaglandin E1 with biodegradable nanoparticles
  Tsutomu Ishihara , Miyuki Takahashi, Megumu Higaki, Mitsuko Takenaga, Tohru Mizushima, and Yutaka Mizushima
  Pharmaceutical Research, Volume 25, Number 7 / July 2008: pp. 1686-1695
• Time-domain optical imaging of sterile soft tissue abscesses with Cy5.5-scVEGF
  Francis Blankenberg, Zoia Levashova, Marina Backer, and Joseph Backer
  Journal of Nuclear Medicine, Volume 49 (Suppl. 1) / 2008
• High-efficacy site-directed drug delivery system using sialyl-Lewis X conjugated liposome
  Noriyasu Hashida, Nobuyuki Ohguro, Noboru Yamazaki, Yukio Arakawa, Eiji Oiki, Hisashi Mashimo, Nobuo Kurokawa, and Yasuo Tano
  Experimental Eye Research, Volume 86, Number 1 / January 2008: pp. 138-149
• Phage display selection of tissue-specific homing peptides and their theragnostic applications (view presentation)
  Byung-Heon Lee
  September 2007
• Tumor-homing chitosan-based nanoparticles for cancer theragnosis; imaging, drug delivery and therapy (view presentation)
  Ick Chan Kwon
  September 2007
• In vivo imaging in experimental preclinical tumor research - a review
  Johannes T. Wessels, A. C. Busse, J. Mahrt, Christian Dullin, E. Grabbe, G. A. Mueller
  Cytometry Part A, Volume 71A, Number 8 / 2007: pp. 542-549
• In vivo time-domain optical imaging of renal ischemia-reperfusion injury: discrimination based on fluorescence lifetime
  Abedelnasser Abulrob, Eric Brunette, Jacqueline Slinn, Ewa Baumann, and Danica Stanimirovic
  Molecular Imaging, Volume 6, Number 5 / September-October 2007: pp. 304-314
• In vivo optical imaging of acute myeloid leukemia by green fluorescent protein: time-domain autofluorescence decoupling, fluorophore quantification, and localization
  Emmet McCormack, David R. Micklem, Lars-Erik Pindard, Elisabeth Silden, Pascal Gallant, Alexandre Belenkov, James B. Lorens, and Bjørn Tore Gjertsen
  Molecular Imaging, Volume 6, Number 3 / May-June 2007: pp. 193-204
• In vitro imaging techniques in neurodegenerative diseases
  Bengt Långström, Per E. Andrén, Örjan Lindhe, Marie Svedberg, and Håkan Hall
  Molecular Imaging and Biology, Volume 9, Number 4 / July 2007: pp. 161-175
• In vivo monitoring the fate of Cy5.5-Tat labeled T lymphocytes by quantitative near-infrared fluorescence imaging during acute brain inflammation in a rat model of experimental autoimmune encephalomyelitis
  Cedric Berger, Hans-Ulrich Gremlich, Philipp Schmidt, Catherine Cannet, Rainer Kneuer, Peter Hiestand, Martin Rausch, and Markus Rudin
  Journal of Immunological Methods, Volume 323, Number 1 / May 2007: pp. 65-77
• Use of fluorescent labeled anti–epidermal growth factor receptor antibody to image head and neck squamous cell carcinoma xenografts
  Eben L. Rosenthal, Brian D. Kulbersh, Teresa King, Tandra R. Chaudhuri, and Kurt R. Zinn
  Molecular Cancer Therapeutics, Volume 6, Issue 4 / April 2007: pp. 1230–1238
• Accumulation of liposome with Sialyl Lewis X to inflammation and tumor region: application to in vivo bio-imaging
  Masahiko Hiraia, Hideki Minematsua, Naoko Kondoa, Kazunori Oiea, Koichi Igarashia, and Noboru Yamazaki
  Biochemical and Biophysical Research Communications, Volume 353, Issue 3 / February 2007: pp. 553-558
• Endorepellin in vivo: targeting the tumor vasculature and retarding cancer growth and metabolism
  Gregory Bix, Remedios Castello, Michelle Burrows, Jason J. Zoeller, Michelle Weech, Rex A. Iozzo, Christopher Cardi, Mathew L. Thakur, Christopher A. Barker, Kevin Camphausen, and Renato V. Iozzo
  Journal of the National Cancer Institute, Volume 98, Number 22 / November 2006: pp. 1634-46
• Tat-functionalized near-infrared emissive polymersomes for dendritic cell labeling
  Natalie A. Christian, Michael C. Milone, Shraddha S. Ranka, Guizhi Li, Paul R. Frail, Kevin P. Davis, Frank S. Bates, Michael J. Therien, P. Peter Ghoroghchian, Carl H. June, and Daniel A. Hammer
  Bioconjugate Chemistry, Volume 18, Number 1 / 2007: pp. 31–40
• Preclinical characterization of amyloid imaging probes with multiphoton microscopy
  Jesse Skoch, Bradley T. Hyman, and Brian J. Bacskai
  Journal of Alzheimer’s Disease, Volume 9, Number 3 (suppl.) / 2006: pp. 401-407
• Far red imaging of Beta-galactosidase activity for stem cell detection in the brain
  Eric Kaijzel, Alexandre Belenkov, Ivo Que, Pierre Couture, and Clemens Löwik
  Society for Molecular Imaging / August 30 – September 2, 2006
• Targeting Beta-3 integrin using a linear hexapeptide labeled with a near-infrared fluorescent molecular probe
  Sharon Bloch, Baogang Xu, Yunpeng Ye, Kexian Liang, Gregory V. Nikiforovich, and Samuel Achilefu
  Molecular Pharmaceutics, Volume 3, Number 5 / September-October 2006: pp. 539-549
• Potassium channels as tumour markers
  Walter Stühmer, Frauke Alves, Franziska Hartung, Marta Zientkowska, and Luis A. Pardo
  FEBS Letters, Volume 580, Issue 12 / May 2006: pp. 2850-2852
• Whole-body fluorescence lifetime imaging of a tumor-targeted near-infrared molecular probe in mice
  Sharon Bloch, Frédéric Lesage, Laura McIntosh, Amir Gandjbakhche, Kexian Liang, and Samuel Achilefu
  Journal of Biomedical Optics, Volume 10, Issue 5 / September/October 2005
• Optical molecular imaging using a novel peripheral benzodiazepine receptor (PBR) - targeted near infrared probe for enhanced in vivo breast cancer detection
  Shelby Wyatt, H. Charles Manning, Pascal Gallant, Guobin Ma, Laura McIntosh, and Darryl Bornhop
  Program and Abstracts, Fourth Annual Meeting of the Society for Molecular Imaging / September 7-10, 2005
• Role of voltage-gated potassium channels in cancer
  Luis A. Pardo, C. Contreras-Jurado, Marta Zientkowska, Frauke Alves, and Walter Stühmer
  Journal of Membrane Biology, Volume 205, Number 3 / June 2005: pp. 115-124
• Cy5.5-DTPA-galactosyl-dextran: a fluorescent probe for in vivo measurement of receptor biochemistry
  David R. Vera, David J. Hall, Carl K. Hoh, Pascal Gallant, Laura M. McIntosh, and Robert F. Mattrey
  Nuclear Medicine and Biology, Volume 32, Issue 7 / 2005: pp. 687-693
• Development of an optical approach for noninvasive imaging of Alzheimer's disease pathology
  Jesse Skoch, Andrew Dunn, Bradley T. Hyman, and Brian J. Bacskai
  Journal of Biomedical Optics, Volume 10, Number 1 / January-February 2005
• A receptor-binding optical imaging agent for the estimation of hepatic receptor concentration
  David R. Vera, Robert F. Mattrey, Carl K. Hoh, and Laura McIntosh
  Excerpt from Program and Abstracts, Second Annual Meeting of the Society for Molecular Imaging / August 15-18, 2003

Topics in Optical Imaging

• A microcomputed tomography guided fluorescence tomography system for small animal molecular imaging
  Dax Kepshire, Niculae Mincu, Michael Hutchins, Josiah Gruber, Hamid Dehghani, Justin Hypnarowski, Frédéric Leblond, Mario Khayat, and Brian W. Pogue
  Review of Scientific Instruments, Volume 80, Number 4 / 2009
• Semiautomatic landmark-based two-dimensional-three-dimensional image fusion in living mice: correlation of near-infrared fluorescence imaging of Cy5.5-labeled antibodies with flat-panel volume computed tomography
  Christian Dullin, Marta Zientkowska, Joanna Napp, Jeannine Missbach-Guentner, H.W. Krell, Friedemann Müller, E. Grabbe, L.F. Tietze, and Frauke Alves
  Molecular Imaging, Volume 8, Number 1 / January-February 2009: pp. 2-14
• Estimating the depth and lifetime of a fluorescent inclusion in a turbid medium using a simple time-domain optical method
  Sung-Ho Han and David J. Hall
  Optics Letters, Volume 33, Number 9 / May 2008: pp. 1035-1037
• Separation of target fluorescence signal from in vivo autofluorescence background based on their temporal signatures
  Guobin Ma, Bruno Guerrero, Anader Benyamin-Seeyar, and Mario Khayat
  Conference Paper, Biomedical Optics (BIOMED), St. Petersburg, Florida / March 16, 2008
• A comparison between a time-domain and continuous wave small animal optical imaging system
  Shay Keren, Olivier Gheysens, Craig S. Levin, and Sanjiv S. Gambhir
  IEEE Transactions on Medical Imaging, Volume 27, Number 1 / January 2008: pp. 58-63
• Diffuse optical tomography and spectroscopy performance assessment: phantoms and methodology
  Niculae Mincu, Jean Brunette, Olga Guilman, Frédéric Leblond, Salim Djeziri, Zahia Ichalalene, Guobin Ma, Mario Khayat, and Anader Benyamin-Seeyar
  Proceedings of SPIE, Volume 6870 / 2008
• Full path Monte Carlo simulation of fluorescence in non-voxelized complex heterogeneous mouse model
  Jean-François Delorme, Guobin Ma, Frédéric Lesage, Frédéric Leblond, and Anader Benyamin-Seyar
  Proceedings of SPIE, Volume 6854 / 2008
• Characterization of natural fluorescence in mice
  Salim Djeziri, Guobin Ma, Niculae Mincu, Anader Benyamin Seeyar, and Mario Khayat
  Proceedings of SPIE, Volume 6850 / 2008
• Fluorescence lifetime estimation of multiple near-infrared dyes in mice
  Guobin Ma, Simon Fortier, Muriel Jean-Jacques, Niculae Mincu, Frédéric Leblond, Zahia Ichalalene, Anader Benyamin-Seeyar, and Mario Khayat
  Proceedings of SPIE, Volume 6850 / 2008
• Strategies to minimize background autofluorescence in live mice during noninvasive fluorescence optical imaging
  Srabani Bhaumik, Jeannette DePuy, and June Klimash
  Lab Animal, Volume 36, Number 8 / 2007
• Diffuse optical fluorescence imaging: sensitivity to heterogeneities and autofluorescence
  Frédéric Leblond and Simon Fortier
  Joint Molecular Imaging Conference / 2007
• Diffuse optical tomography forward model refinements in media with heterogeneous optical properties
  Simon Fortier and Frédéric Leblond
  Proceedings of SPIE, Volume 6629 / 2007
• Preliminary results from a multi-wavelength time-domain optical molecular imaging system
  David J. Hall and Sung-Ho Han
  Proceedings of SPIE, Volume 6430 / 2007
• Sensitivity characterization of a time-domain fluorescence imager: eXplore Optix
  Guobin Ma, Pascal Gallant, and Laura McIntosh
  Applied Optics, Volume 46, Issue 10 / 2007: pp.1650-1657
• Comparison of simplified Monte Carlo simulation and diffusion approximation for the fluorescence signal from phantoms with typical mouse tissue optical properties
  Guobin Ma, Jean-François Delorme, Pascal Gallant, and David A. Boas
  Applied Optics, Volume 46, Issue 10 / 2007: pp. 1686-1692
• Improved quantification of fluorescence in 3-D in a realistic mouse phantom
  Subhadra Srinivasan, Brian W. Pogue, Scott Davis, Frédéric Leblond
  Proceedings of SPIE, Volume 6434 / 2007
• Numerical optix: a time-domain simulator of fluorescent light diffusion in turbid medium
  Guobin Ma, Jean-François Delorme, Olga Guilman, Frédéric Leblond, and Mario Khayat
  Proceedings of SPIE, Volume 6434 / 2007
• Diffuse optical fluorescence tomography using time-resolved data acquired in transmission
  Frédéric Leblond and Simon Fortier
  Proceedings of SPIE, Volume 6431 / 2007
• Sensitivity characterization of a time-domain fluorescence imager: eXplore Optix (view poster)
  Guobin Ma, Pascal Gallant, and Laura McIntosh
  Applied Optics, Volume 46, Number 10 / April 2007: pp. 1650-7
• Data subset algorithm for computationally efficient reconstruction of 3-D spectral imaging in diffuse optical tomography
  Subhadra Srinivasan, Brian W. Pogue, Hamid Dehghani, Frédéric Leblond, and Xavier Intes
  Optics Express, Volume 14, Issue 12 / 2006: pp. 5394-5410
• Comparison of simplified Monte Carlo simulation and diffusion approximation for fluorescent signal from phantoms with typical mouse optical properties (view poster)
  Guobin Ma, Jean-François Delorme, Pascal Gallant, and David A. Boas
  Conference Paper, Biomedical Topical Meeting, Poster Session III / March 19, 2006
• System IRF impact on fluorescence lifetime fitting in turbid medium
  Guobin Ma, Niculae Mincu, Frédéric Lesage, Pascal Gallant, and Laura McIntosh
  Proceedings of SPIE, Volume 5699, Issue 263 / 2005
• Biomedical applications of fluorescence imaging in vivo
  Moinuddin Hassan and Brenda A. Klaunberg
  Comparative Medicine, Volume 54, Number 6 / December 2004: pp. 635-644
• Simple time-domain optical method for estimating the depth and concentration of a fluorescent inclusion in a turbid medium
  David Hall, Guobin Ma, Frédéric Lesage, and Yong Wang
  Optics Letters, Volume 29, Number 19 / 2004: pp. 2258-2260
• In vivo multi-lifetime discrimination using time-domain fluorescence imaging
  Frédéric Lesage and Alexandre Belenkov
  IEEE International Symposium on Biomedical Imaging / April 15-18, 2004
• A quantitative time-domain optical imager for small animal in vivo fluorescence studies
  Pascal Gallant, Alexandre Belenkov, Guobin Ma, Frédéric Lesage, Yong Wang, David Hall, and Laura McIntosh
  Annual Conference of the Optical Society of America / April 14, 2004
• Quantitative fluorescence depth and concentration recovery in turbid media using a time-domain optical small animal imager
  Pascal Gallant, Frédéric Lesage, Guobin Ma, Yong Wang, David Hall, and Laura McIntosh
  Annual Meeting of the Academy of Molecular Imaging / March 27-31, 2004
• Fluorescence lifetime imaging in turbid media using a time-domain optical imager
  Alexandre Belenkov, Guobin Ma, Pascal Gallant, and Laura McIntosh
  Annual Meeting of the Academy of Molecular Imaging / March 29, 2004
• Fluorescence lifetime and quantitative volumetric measurements using time-domain small animal optical imaging
  Laura McIntosh, Pascal Gallant, Alexandre Belenkov, S. Authier, S. Fournier, and A. Nelson
  Annual Meeting of the American Association for Cancer Research / March 28, 2004
• Preclinical optical molecular imager (white paper)
  ART Advanced Research Technologies Inc. / January 2004
• Optical molecular imaging: time-domain advantages with eXplore Optix (white paper)
  William Long and Marcia L. Vernon
  Institut national d'optique / January 2004
• Optical imaging and quantitation
  David J. Hall, Guobin Ma, Frédéric Lesage, and Pascal Gallant
  Contrast Media Research Symposium / October 28-November 1, 2003