Preclinical

Enclosure

Dimensions (W x D x H)

72 cm x 77 cm x 77 cm (28.0 in. x 30.0 in. x 30.0 in.)

Weight (maximum)

110 kg (240 lbs)

General description

Light-tight enclosure with built-in computer system, status lights, and animal handling controls, as well as integrated illumination, detection, and scanning subassemblies.

Installation

Tabletop

Noise level

< 55 dB

Operating conditions
   Temperature
   Acceptable temperature fluctuations
   Relative humidity
   Atmospheric pressure

   20°C to 26°C
   < 2°C change in 15 minutes
   20% to 75% (recommended)
   70 kPa to 106 kPa

Power requirements
   North America
   European Union
   China
   Japan

   115 VAC ± 10% (protective earth), 60 Hz
   230 VAC ± 10% (protective earth), 50 Hz
   220 VAC ± 10% (protective earth), 50 Hz
   100 VAC ± 10% (protective earth), 50/60 Hz

Power consumption

300 VA

Transportation and storage
   Temperature
   Relative humidity
   Altitude

   5°C to 30°C
   Up to 95%
   Up to 40,000 ft (12 192 meters)

Product Classification

Electrical classification

Class 1 (Electrical – IEC 61010-1)

Electromagnetic compatibility

Class A, Group 1 (EMC – CISPR 11)

Laser classification

Laser Class 1 Equipment (Laser – IEC 60825-1)

Product Certification

FDA/CDRH, CE marked, CSA and UL approved

Illumination System

Time domain illumination sources
   Available wavelengths

Between 1 and 4 fixed wavelength pulsed lasers (integrated within enclosure)
   470 nm (± 5 nm)
   635 nm (- 5 nm / + 3 nm)
   665 nm (± 5 nm)
   735 nm (± 5 nm)
   785 nm (- 10 nm / + 0 nm)

Laser pulse repetition rates
   630 to 900 nm wavelength range

   Wavelengths less than 630 nm

   2.5, 5, 10, 20, 40, and 80 MHz ± 1%
   (standard calibrations at 20 and 80 MHz)
   2.5, 5, 10, 20, and 40 MHz ± 1%
   (standard calibrations at 20 and 40 MHz)

Tunable multi-wavelength pulsed laser

480 nm to 780 nm spectral range

CW illumination sources

532 nm (± 5 nm) continuous wave laser

Maximum power (on the specimen table)
   470 nm pulsed laser
   635 nm pulsed laser
   670 nm pulsed laser
   735 nm pulsed laser
   785 nm pulsed laser
   532 nm CW laser

   0.33 mW
   1.00 mW
   1.00 mW
   1.00 mW
   1.00 mW
   10.0 to 20.0 mW

Detection System

Principle of operation

Time-correlated single photon counting system

Enhanced dynamic range and sensitivity

˜ 90 dB, (equivalent to > 30 Bits CCD)

Fluorescence filters

Selectable from eight or twelve-position filter wheel
See Laser Kits for descriptions of the fluorescence filters

Measurable fluorescence lifetime range

0.3 ns to 150 ns

Scanning System

Principle of operation

3D raster scanning with X-Y-Z translation stage

Maximum scan volume (W x D x H)

190 mm x 100 mm x 50 mm

Focal plane adjustments

Set automatically to profile height for optimal results

Region of interest
   Size
   Types
   Scan step

   Any size ROI within maximum scan volume
   Full specimen, rectangle, polygon, line, point
   Selectable between 0.5 and 3.0 mm

Specimen types

In vivo, ex vivo, microplate, bioluminescence

Scan types

Full quantitative and intensity

CCD camera
   Field of view (W x D)
   Alignment resolution
   Alignment accuracy

Provides live view and profilometry measurements
   250 mm x 150 mm
   < 0.1 mm
   < 0.25 mm

Profilometry Measurement

Principle of operation

Optical triangulation

Scan volume (W x D x H)

Highly accurate within 190 mm x 100 mm x 50 mm scan volume

Laser wavelength

670 nm ± 20 nm

Maximum power (on the specimen table)

15.0 mW

Profilometry camera

See CCD Camera for a description of the live view/profilometry camera

Animal Handling

Number of animals

Up to five simultaneously with five-mouse bed

Animal comfort
   Bed types
   Box types

Heated platform for animal imaging beds and boxes
   Standard single-mouse, five-mouse, optical-CT fusion
   Isolation chamber

Heated platform
   Monitoring range
   Control range
   Control accuracy

   15°C and 45°C
   28°C to 42°C
   ± 1°C

Specimen monitoring
   Movement detection
   Vital signs

   Stops measurements automatically if a significant animal position change is detected
   Customizable

Inhalation anesthesia
   Bed types with integrated nose cones

Enclosure ports for isoflurane and oxygen
   Standard single-mouse, five-mouse, optical-CT fusion

Integrated Computer System

CPU
   Primary memory (RAM)
   Secondary memory (HDD)

Pentium 4, 3 GHz or higher
   ≥ 2 GB
   ≥ 500 GB

USB data rate

Hi-speed USB 2.0

Graphic interface memory

256 MB unified memory or more

Sound interface output mode

Stereo 5.1 or better (standard mono speaker provided)

Optical drive
   Type
   Read speed
   Write speed
   Rewrite speed
   Disc loading

DVD writer
   ±RW
   CD(24x), DVD(8x) or faster
   CD(24x), DVD±R(8x) or faster
   CD(24x), DVD±RW(4x) or faster
   Slot, vertical

Monitor type
   Diagonal size
   Maximum resolution
   Maximum SYNC rate
   Color

Flat panel display, TFT active matrix
   19 in. or more
   1600 x 1280 or more
   75 Hz x 80 KHz (V x H)
   Black

USB keyboard

Standard English keyboard with numerical keypad, black

USB mouse

Optical three-button mouse with scroll wheel, black

System Software

Operating system

Windows 7 Professional (32 bit)

Application Software

OptiScan acquisition software

Automates data acquisition with optimized laser power levels for each scan point
Provides built-in tests that support self-diagnostics
Automatically names and archives results data

OptiView analysis software

Processes raw data and allows background fluorescence removal
Displays intensity, lifetime, depth, and concentration measurements

OptiView 3D Reconstruction module

Generates volumetric data from time-resolved measurements

OptiView CT-Fusion module

Exports optical datasets in DICOM file format for fusion with CT images

Enclosure Interface Panel

Monitor interface port

DB 15 HD connector

Monitor power outlet port

C13 power outlet

Keyboard interface port

USB 2.0

Mouse interface port

USB 2.0

Network interface port

8P8C connector (1000Base-T Cat6, RJ-45 compatible)

Accessible USB ports

2 or more

External laser ports
   Laser optical port
   Laser interlock port
   Communication port
   Synchronization port
   Laser control port

   FC (female) connector
   Miniature interlock (male) connector
   USB 2.0
   SMA (female) connector
   DB-9 connector