Imaging Agents
The Fenestra™ line of imaging agents provides flexible, long-lasting contrast enhancement for microCT imaging applications, including vascular and hepatobiliary anatomy and function. With Fenestra, you can achieve soft tissue or vascular contrast from a single administration that can help delineate structures with similar or identical contrast properties. Because Fenestra can be administered repeatedly, imaging data can be collected in the same specimen over the entire course of a study and eliminate the need to sacrifice and assay animals at individual time points.
Unmatched contrast enhancement
- Whole-body, sub-millimeter vascular visualization and superior soft-tissue delineation from a single-dose administration that can last for several hours.
- Correlation between image enhancement and biochemical function in certain organs and tissues and detailed visualization of solid tumors and tumor vasculature in multiple animal species.
- Quantification of physiologic parameters, such as vessel permeability and tissue perfusion.
that is simple to use in a wide range of applications.
- Low viscosity, isotonic formulation with an excellent safety profile that is compatible with repeat dosing in multiple species.
- No need to engineer genes or reporter systems into the animal or to sacrifice and assay animals at individual time points.
- Used in oncology, cardiovascular, and hepatic disease research to evaluate therapeutic efficacy and for drug screening and development.
“Previous efforts in our imaging studies using more conventional iodinated contrast agents were less successful because of the rapid clearance of the contrast agent and the resulting variation in contrast levels over the course of the study. Because of the long-lasting, stable contrast enhancement afforded by Fenestra VC, our image quality and ease of image interpretation have improved substantially. We look forward to using Fenestra VC to extend the utility of our imaging equipment into new areas of cardiovascular imaging and image-based phenotyping of small animals.”
G. Allan Johnson, PhD
Duke Department of Radiology
