Frequently Asked Questions
- Can Fenestra imaging agents provide longer lasting contrast enhancement than other products?
- Does using Fenestra imaging agents necessitate any special laboratory procedures?
- What dose of Fenestra should I use?
- Can I use Fenestra in animals other than mice?
- Can I use Fenestra VC instead of LC to image liver parenchyma and hepatobiliary diseases?
Can Fenestra imaging agents provide longer lasting contrast enhancement than other products?
Yes. Fenestra's unique oil-in-water lipid emulsion formulation, which selectively localizes iodinated lipids to various sites in the body, provides comparatively longer and more stable in vivo residence times than standard water soluble contrast media. For more information about the benefits of using Fenestra imaging agents, refer to our Technology section.
Does using Fenestra imaging agents necessitate any special laboratory procedures?
No. Fenestra contrast agents are non-toxic, non-radioactive, and do not contain active or biological products. Special care is NOT required for storage, handling, usage, or disposal.
What dose of Fenestra should I use?
Detailed user guides that provide instructions for preparation, use, and dosage, as well as tips to help optimize your study, are available in our Product Documentation section.
Can I use Fenestra in animals other than mice?
Yes. Fenestra has been used successfully in multiple animal species — rats, rabbits, dogs, woodchucks, monkeys, and pigs. You should note that optimal dosing can differ between animals and specific applications. Contact our Application Support department for information about adapting the use of Fenestra.
Can I use Fenestra VC instead of LC to image liver parenchyma and hepatobiliary diseases?
Yes. Fenestra LC and VC have the same iodine concentration (50 mg iodine/ml) and can be used in exactly the same way. The only notable difference between the two agents is the delay period required between injection and microCT scanning that will provide the best contrast enhancement. You should also note that with Fenestra VC it is possible to distinguish liver vessels and parenchyma when the animal is scanned at different post-injection time points. This can be crucial for total liver volume calculations and enhanced tumor detection.
Refer to the following publications for more information about liver contrast enhancement with Fenestra VC. For the best experimental results, you should always perform a preliminary study to determine the appropriate dosage and scanning time points.
Noninvasive quantification of tumor volume in preclinical liver metastasis models using contrast-enhanced x-ray computed tomography
Graham KC, Ford NL, MacKenzie LT, Postenka CO, Groom AC, MacDonald IC, Holdsworth DW, Drangova M, Chambers AF
Invest Radiol. 2008 Feb;43(2):92-9.PMID: 18197061 [PubMed - indexed for MEDLINE]
Time-course characterization of the computed tomography contrast enhancement of an iodinated blood-pool contrast agent in mice using a volumetric flat-panel equipped computed tomography scanner
Ford NL, Graham KC, Groom AC, Macdonald IC, Chambers AF, Holdsworth DW
Invest Radiol. 2006 Apr;41(4):384-90.PMID: 16523021 [PubMed - indexed for MEDLINE]