Scientific Publications
Publications
- Functional Imaging Using Diffuse Optical Spectroscopy of Neoadjuvant Chemotherapy Response in Women with Locally Advanced Breast Cancer
H. Soliman, A. Gunasekara, M. Rycroft, J. Zubovits, R. Dent, J. Spayne, M. J.Yaffe, and G. J. Czarnota
Clinical Cancer Research; 16(9); 2605–14 (2010) - Imaging Breast Cancer Chemotherapy Response with Light
Bruce J. Tromberg and Albert E. Cerussi
Clinical Cancer Research; 16(9); 2486–8 (2010) - Translational Multimodality Optical Imaging
Refer to Chapter 14: Mario Khayat, Clinical Studies in Optical Imaging: An Industry Perspective
Fred S. Azar and Xavier Intes, Editors ISBN 978-1-59693-307-1 (2008) - Optical tomography as adjunct to x-ray mammography: methods and results
This work presents prospective tissue characterization results from a multi-site clinical study targeting optical tomography as an adjunct to conventional mammography. Application specific algorithms based on a diffusive model of light transport were used to quantify the breast's optical properties and derive 3D images of physiological indices.
Mario Khayat, Zahia Ichalalene, Niculae Mincu, Fredéric Leblond, Olga Guilman, and Salim Djeziri
Proceedings of the SPIE 6431, 64310F (2007) - Sensitivity and repeatability of diffuse optical tomography: towards breast cancer neoadjuvant treatment monitoring
It is expected that the optical signatures of physiological changes are biomarkers reacting faster to breast tumor evolution than structural changes, meaning that diffuse optical tomography (DOT) could be a promising modality for monitoring and detecting early changes of the lesion during neoadjuvant treatment.
Niculae Mincu, Salim Djeziri, Zahia Ichalalène, Fréderic Leblond, and Mario Khayat
Proceedings of the SPIE 6434, 64341D (2007) - Data subset algorithm for computationally efficient reconstruction of 3-D spectral imaging in diffuse optical tomography
Three-dimensional (3-D) models of light propagation in diffuse optical tomography provide an accurate representation of scattering in tissue. Here, the use of spectral priors, shown to improve quantification of functional parameters in 2D, has been extended to 3D. To make 3D spectral imaging computationally tractable, a novel technique is presented to deal with the large data set.
S. Srinivasan, B.W. Pogue, H. Dehghani, F. Leblond, X. Intes
Optics Express 14(12), 5394-5410 (2006) - Time-Domain Optical Mammography SoftScan®: Initial Results
This engineering optimization study illustrates the sensitivity of near-infrared (NIR) optical techniques to the metabolic functions of breast tissue. Using the non-invasive SoftScan® system, 49 women underwent tests resulting in statistically significant discrimination of malignant and benign tissue based on their deoxy-hemoglobin content.
X. Intes, S. Djeziri, Z. Ichalalene, N. Mincu, Y. Wang, P. St-Jean F. Lesage, D. Hall, D. Boas, M. Polyzos, D. Fleiszer, B. Mesurolle
Academic Radiology 12, 934-947 (2005) - Time Domain Fluorescent Diffuse Optical Tomography: Analytical expressions
Proper physical models of light propagation are necessary to monitor the bio-distribution of molecular contrast agents in thick tissue. To recover 3D concentrations of the compound distribution, it is necessary to perform a model based inverse problem: Diffuse Optical Tomography. In this work, we focus on Fluorescent Diffuse Optical Tomography expressed within the normalized Born approach.
S. Lam, F. Lesage, X. Intes
Optics Express 13(7), 2263 - 2275 (2005) - Non-PET Functional Imaging Techniques: Optical
The promises of optical imaging techniques are manifold and recent research developments have the potential of benefiting many medical fields. This article focuses on diffuse optical techniques based on near-infrared (NIR) radiation.
X. Intes, B. Chance
Radiologic Clinics of North America 43(1), 221-234 (2005) - Time Domain Fluorescent Diffuse Optical Tomography
S. Lam, F. Lesage, X. Intes
Proceedings of the SPIE 5578, 179-187 (2004) - Time-domain optical mammography SoftScan: Initial results on detection and characterization of breast tumors
X. Intes, S. Djeziri, Z. Ichalalene, N. Mincu, Y. Wang, P. St-Jean, F. Lesage, D. Hall, D. Boas, M. Polyzos
Proceedings of the SPIE 5578, 188-197 (2004)
Conferences
- Time-Domain Optical Imaging: Toward Clinical Applications
Mario Khayat, CLEO/Phast -2007- Invited speaker
Symposium on Biophotonics and Applications, Baltimore, MD, May 2007 - Lesion Discrimination with Optical Mammography: Preliminary Evaluation
Nathalie Duchesne, MD, Benoit Mesurolle, MD, David Fleiszer, MD, Isabelle Trop, MD, Lucie Lalonde, MD, Raymond Taillefer, MD, Joe Kozikowski, MD, Mario Khayat, M. Eng.
Annual Meeting of Canadian Association of Radiologists - October 22-55, 2006 - Functional Oxy-Haemoglobin and Scattering Indices for In-Vivo Characterization of Breast Cancer
Significant discrimination between malignant and healthy tissue based on the oxy-haemoglobin index in the breast was observed, with sensitivity and specificity rates of 88%. Also, the scatter component recovered through SoftScan’s time domain optical imaging technology presented a higher contrast in the diseased subjects, relative to the benign and healthy populations, thus providing a further indication of the changes in the microscopic structure of the tissues and blood vessels that are affected by the onset of cancer...
Zahia Ichalalène, Joe Kozikowski, Salim Djeziri, Samira Mezziani, Frédéric Leblond, Niculae Mincu, Mario Khayat
First AACR International Conference on Molecular Diagnostics in Cancer Therapeutic Development - September 12-15, 2006 - Three-Dimensional Optical Imaging Using Spectral Constraints
A novel scheme for implementing spectral constraints into a three-dimensional (3-D) image reconstruction model is presented here. Based on preferentially choosing measurements to be used in the image formation process, based on information relating to spatial areas of maximum heterogeneity, the incorporation of spectral constraints, shown to provide improved functional information (in 2-D) was made computationally efficient and feasible in a 3-D setting.
S. Srinivasan, B.W. Pogue, F. Leblond
OSA Biomedical Optics – March 19-23, 2006 - Optical Breast Imaging: SoftScan System
Optical mammography is a new modality targeting breast cancer diagnosis and monitoring. It provides functional information on the physiological status of tissue using near-infrared light. Results of a clinical study involving the SoftScan time-domain imaging system are reviewed with emphasis on instrumentation and data analysis improvements.
S. Djeziri, O. Guilman, Z. Ichalalene, F. Leblond, M. Khayat, N. Mincu
OSA Biomedical Optics – March 19-23, 2006 - Optical Time Domain Imaging: from mouse to human
X. Intes
Photonics West, San Jose CA, January 21, 2006 and AIPR: Multi-Modal Imaging, Washington DC, October 19-21, 2005